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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
13.33
Human Site:
T1124
Identified Species:
20.95
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
T1124
S
V
T
D
S
G
P
T
F
N
Y
L
L
D
M
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
D1150
S
G
T
P
S
G
P
D
F
N
Y
I
L
N
M
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
D1136
S
G
T
P
S
G
P
D
F
N
Y
I
L
N
M
Dog
Lupus familis
XP_537646
1532
174610
T1124
S
V
R
D
S
G
P
T
F
N
Y
L
L
D
M
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
T1121
S
A
A
E
A
G
P
T
F
N
Y
L
L
D
M
Rat
Rattus norvegicus
P41516
1526
173202
T1121
P
A
A
E
S
G
P
T
F
N
Y
L
L
D
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
D1152
S
T
S
A
T
G
P
D
F
N
Y
L
L
E
M
Chicken
Gallus gallus
O42130
1553
174974
D1116
S
A
A
A
T
G
P
D
F
N
Y
L
L
N
M
Frog
Xenopus laevis
NP_001082502
1579
178601
D1114
E
A
N
A
T
G
P
D
F
N
Y
L
L
S
M
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
D1120
K
E
D
T
S
G
P
D
Y
N
Y
L
L
S
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
M1078
E
W
Q
R
R
I
K
M
E
D
A
E
Q
A
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
S1138
K
L
K
E
L
R
E
S
G
E
I
E
L
D
E
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
Q1078
E
S
S
K
L
N
N
Q
A
R
F
I
M
E
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
A1094
A
G
A
V
D
D
D
A
A
E
E
P
E
E
I
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
R1059
L
E
N
L
G
F
P
R
F
N
K
E
G
K
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
66.6
66.6
93.3
N.A.
73.3
73.3
N.A.
60
60
53.3
53.3
N.A.
0
N.A.
13.3
0
P-Site Similarity:
100
80
80
93.3
N.A.
86.6
80
N.A.
80
73.3
60
60
N.A.
6.6
N.A.
33.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
27
27
20
7
0
0
7
14
0
7
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
7
14
7
7
7
40
0
7
0
0
0
34
7
% D
% Glu:
20
14
0
20
0
0
7
0
7
14
7
20
7
20
7
% E
% Phe:
0
0
0
0
0
7
0
0
67
0
7
0
0
0
0
% F
% Gly:
0
20
0
0
7
67
0
0
7
0
0
0
7
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
7
0
0
0
0
7
20
0
0
7
% I
% Lys:
14
0
7
7
0
0
7
0
0
0
7
0
0
7
7
% K
% Leu:
7
7
0
7
14
0
0
0
0
0
0
54
74
0
0
% L
% Met:
0
0
0
0
0
0
0
7
0
0
0
0
7
0
67
% M
% Asn:
0
0
14
0
0
7
7
0
0
74
0
0
0
20
0
% N
% Pro:
7
0
0
14
0
0
74
0
0
0
0
7
0
0
7
% P
% Gln:
0
0
7
0
0
0
0
7
0
0
0
0
7
0
0
% Q
% Arg:
0
0
7
7
7
7
0
7
0
7
0
0
0
0
0
% R
% Ser:
47
7
14
0
40
0
0
7
0
0
0
0
0
14
0
% S
% Thr:
0
7
20
7
20
0
0
27
0
0
0
0
0
0
0
% T
% Val:
0
14
0
7
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
7
0
67
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _